High Protein Italian Beef and Pasta Bake

Featured in: Oven-Baked Meals

This comforting Italian-American bake combines lean ground beef with whole wheat pasta, colorful vegetables, and a rich tomato sauce. Topped with melted mozzarella and Parmesan, it delivers 33 grams of protein per serving while keeping calories in check.

The dish comes together in just 50 minutes, making it ideal for weeknight dinners or Sunday meal prep. Turkey pepperoni adds a pizza-inspired twist without excess fat, while vegetables like bell peppers, mushrooms, and spinach boost nutrition.

Leftovers reheat beautifully for lunches throughout the week.

Updated on Mon, 26 Jan 2026 01:27:14 GMT
Golden, bubbling mozzarella and Parmesan top this hearty Italian-American pasta bake, packed with lean ground beef, vegetables, and whole wheat penne for a satisfying family dinner. Pin it
Golden, bubbling mozzarella and Parmesan top this hearty Italian-American pasta bake, packed with lean ground beef, vegetables, and whole wheat penne for a satisfying family dinner. | tastysfenj.com

This High Protein Italian Beef and Pasta Bake is a wholesome, pizza-inspired meal that combines the comforting flavors of melty cheese and savory beef with nutritious vegetables and whole wheat pasta. Perfectly modified for a high-protein diet, it's an easy-to-make dish that satisfies the whole family while supporting your health goals.

Golden, bubbling mozzarella and Parmesan top this hearty Italian-American pasta bake, packed with lean ground beef, vegetables, and whole wheat penne for a satisfying family dinner. Pin it
Golden, bubbling mozzarella and Parmesan top this hearty Italian-American pasta bake, packed with lean ground beef, vegetables, and whole wheat penne for a satisfying family dinner. | tastysfenj.com

With a blend of lean ground beef, fresh spinach, and mushrooms, this pasta bake delivers a rich, savory experience in every bite. It’s designed to be both filling and flavorful, using crushed tomatoes and aromatic herbs like oregano and basil to create a sauce that tastes just like your favorite pizzeria specialty.

Ingredients

  • Pasta: 300 g (10.5 oz) whole wheat penne or rotini
  • Beef & Vegetables: 450 g (1 lb) extra-lean ground beef, 1 medium onion (diced), 2 cloves garlic (minced), 1 red bell pepper (diced), 100 g (3.5 oz) mushrooms (sliced), 100 g (3.5 oz) baby spinach
  • Sauce: 700 ml (24 oz) canned crushed tomatoes, 2 tbsp tomato paste, 1 tsp dried oregano, 1 tsp dried basil, ½ tsp chili flakes (optional), salt and freshly ground black pepper to taste
  • Cheese & Toppings: 150 g (5 oz) part-skim mozzarella cheese (shredded), 30 g (1 oz) grated Parmesan cheese, 30 g (1 oz) turkey pepperoni slices (optional), fresh basil for garnish (optional)
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Instructions

Step 1
Preheat oven to 200°C (400°F).
Step 2
Cook pasta in a large pot of boiling salted water until al dente. Drain and set aside.
Step 3
In a large nonstick skillet over medium heat, cook the ground beef until browned, breaking it up as it cooks. Drain excess fat if needed.
Step 4
Add onion, garlic, bell pepper, and mushrooms to the skillet. Sauté for 5–7 minutes until softened.
Step 5
Stir in spinach and cook until wilted, about 1 minute.
Step 6
Add crushed tomatoes, tomato paste, oregano, basil, chili flakes, salt, and pepper. Simmer for 5 minutes, allowing flavors to meld.
Step 7
Combine the cooked pasta with the beef and vegetable sauce mixture.
Step 8
Transfer the mixture to a lightly greased 23x33 cm (9x13 inch) baking dish.
Step 9
Sprinkle mozzarella and Parmesan evenly over the top. Arrange turkey pepperoni slices if using.
Step 10
Bake for 20 minutes, until cheese is melted and bubbly.
Step 11
Garnish with fresh basil before serving, if desired.

Zusatztipps für die Zubereitung

To ensure the best texture, cook the pasta just until it is al dente, as it will continue to soften while baking in the oven. For the ground beef, make sure to drain any excess fat after browning to keep the dish light and prevent the sauce from becoming greasy.

Varianten und Anpassungen

For an extra protein boost, stir 200 g of low-fat cottage cheese or ricotta into the pasta mixture before baking. You can also use chickpea or lentil pasta for a gluten-free option that is even higher in protein.

Serviervorschläge

Serve this hearty Italian-American bake with a crisp green salad to balance the rich tomato and cheese flavors. You can also add black olives or roasted zucchini to the vegetable mix for a more Mediterranean-inspired flavor profile.

A close-up of the high-protein Italian beef and pasta bake, featuring melty cheese, fresh basil garnish, and savory turkey pepperoni slices for a pizza-inspired twist. Pin it
A close-up of the high-protein Italian beef and pasta bake, featuring melty cheese, fresh basil garnish, and savory turkey pepperoni slices for a pizza-inspired twist. | tastysfenj.com

This high-protein pasta bake is a delicious and satisfying way to enjoy classic Italian flavors while staying on track with your nutritional goals. It's the perfect solution for a hearty family dinner or healthy weekly meal prep.

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Recipe Questions & Answers

Can I freeze this pasta bake?

Yes, assemble the entire dish before baking and wrap tightly. Freeze for up to 3 months. Thaw overnight in the refrigerator and bake as directed, adding about 10 extra minutes if needed.

What pasta works best for this bake?

Whole wheat penne or rotini holds sauce well and adds fiber. For gluten-free options, try chickpea or lentil pasta, which also increases protein content significantly.

How can I make this even higher in protein?

Stir 200 g low-fat cottage cheese or ricotta into the pasta mixture before baking. You can also add extra lean ground beef or use high-protein pasta alternatives.

Can I make this vegetarian?

Replace the ground beef with plant-based crumbles or extra vegetables like zucchini, eggplant, and more mushrooms. Add lentils or white beans for protein to maintain the nutritional profile.

What can I serve alongside this bake?

A crisp green salad with vinaigrette balances the richness. Roasted vegetables or steamed broccoli also complement the dish well. Garlic bread makes for a more indulgent meal.

How long will leftovers keep in the refrigerator?

Store in an airtight container for up to 4 days. Reheat individual portions in the microwave or cover the baking dish with foil and warm in a 180°C (350°F) oven until heated through.

High Protein Italian Beef and Pasta Bake

Hearty beef and pasta bake loaded with vegetables and topped with melted mozzarella and Parmesan cheese.

Prep time
20 min
Time to cook
30 min
Overall time
50 min
Created by Benjamin Holloway

Recipe type Oven-Baked Meals

Skill level Easy

Cuisine type Italian-American

Makes 6 Number of servings

Dietary details None specified

What You'll Need

Pasta

01 10.5 oz whole wheat penne or rotini pasta

Beef & Vegetables

01 1 lb extra-lean ground beef
02 1 medium onion, diced
03 2 cloves garlic, minced
04 1 red bell pepper, diced
05 3.5 oz mushrooms, sliced
06 3.5 oz baby spinach

Sauce

01 24 fl oz canned crushed tomatoes
02 2 tablespoons tomato paste
03 1 teaspoon dried oregano
04 1 teaspoon dried basil
05 ½ teaspoon chili flakes, optional
06 Salt and freshly ground black pepper to taste

Cheese & Toppings

01 5 oz part-skim mozzarella cheese, shredded
02 1 oz grated Parmesan cheese
03 1 oz turkey pepperoni slices, optional
04 Fresh basil for garnish, optional

Directions

Step 01

Preheat Oven: Set oven temperature to 400°F.

Step 02

Cook Pasta: Cook pasta in a large pot of boiling salted water until al dente. Drain and set aside.

Step 03

Brown Ground Beef: In a large nonstick skillet over medium heat, cook the ground beef until browned, breaking it up as it cooks. Drain excess fat if needed.

Step 04

Sauté Vegetables: Add onion, garlic, bell pepper, and mushrooms to the skillet. Sauté for 5 to 7 minutes until softened.

Step 05

Wilt Spinach: Stir in spinach and cook until wilted, approximately 1 minute.

Step 06

Build Sauce: Add crushed tomatoes, tomato paste, oregano, basil, chili flakes, salt, and pepper. Simmer for 5 minutes to allow flavors to meld.

Step 07

Combine Ingredients: Combine the cooked pasta with the beef and vegetable sauce mixture.

Step 08

Transfer to Baking Dish: Transfer the mixture to a lightly greased 9x13 inch baking dish.

Step 09

Top with Cheese: Sprinkle mozzarella and Parmesan evenly over the top. Arrange turkey pepperoni slices if using.

Step 10

Bake: Bake for 20 minutes until cheese is melted and bubbly.

Step 11

Garnish and Serve: Garnish with fresh basil before serving if desired.

What You'll Need

  • Large pot
  • Large nonstick skillet
  • 9x13 inch baking dish
  • Mixing spoon
  • Cheese grater

Allergy info

Review each item for allergens, and talk to a doctor if you're unsure.
  • Contains wheat from pasta
  • Contains milk from cheese and optional cottage or ricotta cheese
  • May contain soy from processed meat or cheese products

Nutrition info (per serving)

Nutrition details are for your reference only and don't replace healthcare guidance.
  • Calories count: 370
  • Fat content: 11 g
  • Carbohydrates: 37 g
  • Protein amount: 33 g